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Methotrexate

Methotrexate is used in instances where active metabolism of the cells needs to be inhibited
Cancer
Generic
Methotrexate

Methotrexate 2.5mg

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Usage

What is Methotrexate uses?

This medicine interferes with the growth of certain cells of your body mainly the cells that reproduce quickly like cancer cells, bone marrow cells as well as skin cells.  

Methotrexate pills are usually used for treating certain types of cancer of the breast, head, lung, skin and neck. This medicine is also very effective in treating serious psoriasis as well as certain forms of rheumatoid arthritis.  

Methotrexate tablets are mainly given after other medications that have been tried without successful treatment of symptoms.  

Methotrexate is also considered as chemotherapy drug as it is very effective in treating different types of cancers. But remember that just like other chemotherapy drugs there are also few side effects of methotrexate. 

Methotrexate generic drug is available in the brand name of Rasuvo and Otrexup. Therefore, you can buy Methotrexate 2.5 mg tablet from our pharmacy at a reasonable price.  

Intrathecal methotrexate is one of the chemotherapy drugs that are given to avoid leukaemia cells to enter into the cerebrospinal fluid around your spine and brain.   

What is the dosage of Methotrexate?

It is very important for you to take Methotrexate 2.5 mg tablet exactly in the same manner as prescribed by your doctor. Strictly follow all the directions that are mentioned on your prescription label and carefully read all the medication guides as well as instruction sheets.  

Methotrexate tablets are sometimes taken just once or twice per week and not every day. Remember that it is very important for you to use the correct dose. Some people have died after taking this medicine because they were taking the wrong dose. So if you have any questions or confusion then make sure that you ask your doctor well in advance.  

When taking the liquid form of Methotrexate medication, ensure that you carefully measure the liquid and use the dosing syringe which is provided with the medicine. Remember that you should always use the dosing syringe or a medicine dose-measuring device for measuring the dose. Do not use the kitchen spoon as you might take the wrong dose and land up in trouble.  

Methotrexate oral medication can be toxic for your organs and there are chances that it might lower your blood cell counts. So it is important for you to have a blood test often or as directed by your doctor and also have an occasional liver biopsy. Based on your results, there are chances that your cancer treatment might get delayed.  

In case you are using Methotrexate 2.5 mg tablet and want to be sedated for the dental work then make sure that you inform your doctor well in advance that you are using this medicine.   

Always store the liquid medicine but do not freeze it. Ensure that at least for 60 days you should store your liquid medicine at the room temperature. Therefore, store Methotrexate tablets at room temperature right away from direct heat as well as moisture.   

What if you miss a dose? 

If you miss any dose of this medicine then you need to immediately contact your doctor. Make sure that your prescription is refilled before you run out of medicine entirely.   

What you should avoid while taking Methotrexate? 

During your Methotrexate medication, it is very important for you to avoid the intake of alcohol as it can damage your liver to a great extent. When you are using Methotrexate oral medicine make sure that you do not receive any kind of live vaccine because there are chances that you might suffer from a serious infection. Live vaccines include zoster, measles, polio, typhoid, mumps, varicella, rubella as well as varicella.  

Methotrexate is known to pass into body fluids such as vomit, urine and faeces so it is important for the caregivers to wear rubber gloves when they are cleaning up a patient’s body fluids, changing diapers or handling the contaminated trash as welk as laundry. As a caregiver, it is important for you to wash your hands properly before and after removing the gloves. All the soiled clothing, as well as linens, should be washed separately right away from all other laundries. 

During the intake of Methotrexate tablets make sure that you avoid the exposure to sunlight or artificial UV rays, mainly when you are treated for psoriasis. This medicine is known to make your skin more sensitive to sunlight as well as worsen your psoriasis.  

Can you take Methotrexate during pregnancy? 

Methotrexate is known to affect fertility in both men as well as women. So it is very important for you to use birth control so that you can effectively prevent pregnancy because this medicine can harm your unborn baby if your pregnancy occurs.  

If you use Methotrexate tablets in early pregnancy time it can increase your chance of abortion.  

Can a breastfeeding mother take this medicine? 

During your Methotrexate medication, you should strictly not breast-feed your baby as it can harm a nursing baby. 

How does Methotrexate treat rheumatoid arthritis? 

Methotrexate for arthritis is very effective and this is one of the first medicines that your doctor is going to recommend you when you are diagnosed with rheumatoid arthritis.  

This medicine will help in easing different symptoms of rheumatoid arthritis such as joint pain, swelling, fatigue as well as redness. It is also very effective in preventing the damage to your organs and joints. 

This medicine is used in lupus patient for alleviating the joint pain as well as swelling of polyarthritis. But take the medicine as directed by your doctor. 

Methotrexate works by interrupting the process that often causes RA inflammation which is involved in damaging your joints as well as organs with time. Take this medicine as prescribed by your doctor.  

How does Methotrexate treat psoriasis? 

This medicine treats psoriasis by easing the symptoms of curbing of your immune system and the decreasing the rapid growth of skin cells. You should take this medicine either by mouth or in a shot. After your medication starts, you will be able to see the results after 4 to 6 weeks.    

Can you use Methotrexate for psoriatic arthritis treatment? 

This is one of the drugs that have been used from the last 50 years for treating psoriatic arthritis. It is used either alone or in combination with other therapies, Methotrexate medication is used as a first-line treatment for moderate to severe psoriatic arthritis.   

Precautions to be taken while using Methotrexate 

Remember that stopping and restarting Methotrexate without your doctor’s permission can cause serious side effects. This medicine should not be used if you are allergic to it. Methotrexate tablets should not be used for treating psoriasis or rheumatoid arthritis if you are suffering from:  

  • Low blood cell counts
  • A weak immune system or bone marrow problem
  • Chronic liver disease
  • If you are pregnant or breast-feeding 
  • Cirrhosis as well as alcoholism

This medicine is sometimes given to treat cancer even when patients do have one of the conditions which are stated above. Your doctor is going to decide whether this treatment is right for you or not. Inform your doctor well in advance if you suffer from:

  • Radiation treatments
  • Lung disease
  • Kidney disease
  • Any type of infection

If the father or mother is taking this medicine then Methotrexate tablets can cause birth defects or can even harm an unborn baby.  

If you are a woman, then do not use this medicine for treating rheumatoid arthritis or psoriasis if you are pregnant. It is important for you to have a negative pregnancy test before you start this treatment. Make use of an effective form of birth control during the intake of Methotrexate and also for six months after your last dose.  

IIf you are a man then make use of effective condom so that you can prevent causing pregnancy while taking this medicine. You need to use a condom for at least three months after your last dose.  

In case even after taking precautions pregnancy takes place when either the father or mother is taking this medicine then call your doctor immediately and seek medical help.   

Without the permission of doctor, this medicine should not be given to children.  

How to take Methotrexate in short form? 

It has been seen that shots work better for some people mainly if you forget to take your pills on scheduled time or if the pills cause nausea. Methotrexate liquid form comes in vials with a hypodermic needle or in prefilled pens with different doses.  

You can inject this drug under your skin on your stomach or thigh. Your doctor or nurse will show you once how to do this at home. In case you use a prefilled pen then you need to stick the pen into your stomach or thigh and then press on it in order to inject the drug. In a different spot each time, try giving yourself your shot. When you take this drug in different spots then you have less chance of skin reactions. 

To get the effects of Methotrexate medication it is going to take the time of three to six weeks. There are chances that it might take even more time like 12 weeks in order to give you full effects. Your doctor is going to conduct a blood test often in order to see how well the treatment is working and also see that this drug is not affecting your organs like your liver. 

What are Methotrexate side effects? 

Methotrexate can cause adverse effects if you do not follow the doctor’s direction properly. Methotrexate oral side effects have been seen more in older adults. You need to contact your doctor immediately if you come across any signs of an allergic reaction while using this medicine such as difficulty in breathing, hives as well as swelling in your throat or face. 

Also inform your doctor immediately if you suffer from serious skin reaction like burning in your eyes, fever, red or purple skin rash that is spreading and causing blistering & peeling as well as a sore throat.  

Some of the common side effects of methotrexate pills are:

  • Abnormal liver function tests
  • Fever, headache, mouth sores
  • Tiredness & not feeling well
  • Dizziness, upset stomach
  • Nausea

You need to get the emergency medical help immediately if you have: 

  • Signs of kidney problems like swelling in your feet or ankles, little or no urination
  • Fever, vomiting, blood in your urine or stools
  • Chills, white patches, swollen lymph glands, sores inside your mouth or on your lips
  • Weight loss & night sweats
  • Diarrhoea, dry cough, feeling short of breath, wheezing, cough with mucus and stabbing chest pain
  • Seizure
  • Signs of liver problems such as dark urine, stomach pain in the upper right side and jaundice
  • Signs of tumour cell breakdown such as fast or slow heart rate, confusion, muscle cramps, seizure, tiredness, muscle weakness, numbness or tingling, vomiting as well as diarrhoea
  • Signs of nerve problems such as headache, confusion, loss of movement in any part of your body, feeling irritable, weakness, vision problems, coordination problems, drowsiness and neck stiffness

Thus, this is not the complete list of side effects so if you experience anything apart from this list then contact your doctor immediately.  

Methotrexate Interactions 

Remember that this medicine can harm your liver mainly if you are also using few other medicines for treating infections, birth control, high cholesterol, tuberculosis, heart problems, seizures, depression, hormone replacement, high blood pressure and pain or arthritis medicines. 

Make sure that you inform your doctor about all the drugs that you are taking such as prescription & nonprescription drugs as well as herbal products. There are total 556 drugs that interact with Methotrexate medication.  

120 major drug interactions

420 moderate drug interactions

16 minor drug interactions  

Some of the names of drugs that interact with Methotrexate tablets include amoxicillin, Celebrex, Cymbalta, ibuprofen, diclofenac, Enbrel, prednisone, etc.  

How do Methotrexate works? 

This medicine works by interfering with the cancer cells ability in order to absorb and use folate. 

Methotrexate warnings 

This medicine is not taken on a regular basis usually. You should know your correct dose because many people have died who were taking Methotrexate every day by accident.  


We only ship medications which are approved by FDA, Also please consult your doctor to make a full decision on what medication to take.

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