What is finasteride and what are they used for?
- Finasteride is an over-the- counter orally active drug that was first approved by the FDA in 1992 for the treatment of benign prostatic hyperplasia to improve symptoms and reduce the risk for acute urinary retention or the need for surgical procedures.
- In 1998, these pills were approved by the FDA to treat male pattern hair loss.
- Finasteride is commonly marketed under the brand names Propecia and Proscar to be used alone or in combination with doxazosin, an alpha-blocker.
- Women and children should not use this medication.
How does Finasteride 5mg work (mechanism of action)?
- Finasteride is a synthetic 4-azasteroid compound and specific inhibitor of steroid Type II 5α-reductase, which is an intracellular enzyme that converts the androgen testosterone into 5α-dihydrotestosterone (DHT).
- It is Indicated for the treatment of male pattern hair loss (androgenetic alopecia, hereditary alopecia, or common male baldness) in male patients and for the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate to improve symptoms
What are the side effects of finasteride in men?
- Common side effects include -
- Cold sweats
- Dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
Finasteride dosage for hair loss
- For the treatment of male pattern hair loss (androgenetic alopecia) in men, 18 to 41 years of age with mild to moderate hair loss of the vertex and anterior mid scalp area, dosage is 1 mg orally once a day.
- Daily use of finasteride for 3 months or more is necessary before benefit is observed. Continued use is recommended to sustain benefit.
- Withdrawal of treatment leads to reversal of effect within 12 months.
- Finasteride interacts with 548 drugs
- Therefore, before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.
- Take with or without food. The absorption is unaffected by food.
Finasteride warnings and precautions
- Before taking finasteride, tell your doctor or pharmacist if you are allergic to it or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.
- Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, prostate cancer, infections, urinary problems.
- Your healthcare professionals may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.
- This medication can affect the results of the blood test used to detect prostate cancer (prostatic-specific antigen or PSA levels). Make sure laboratory personnel and your doctors know you use this drug.
- The drug can be absorbed through the skin. If the film coating of the tablet has been broken or the tablet crushed, it should not be handled by a woman who is pregnant or planning to become pregnant. Exposing a developing male infant to finasteride can result in abnormalities of the genitals.
- Finasteride should not be used in women, especially during pregnancy or breast-feeding. It may harm an unborn or breast-feeding baby.
- There were no reported significant adverse events in clinical trials of male patients receiving single oral doses of finasteride up to 400 mg and multiple doses of finasteride up to 80 mg/day for 3 months.
- As there have been no cases of overdose or clinically significant toxicity with finasteride, there are no specific recommendations in case of an overdose.
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