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Home / Cancer / Cyclophosphamide

Cyclophosphamide

Cyclophosphamide is a non-steroidal and anti-androgen drug. It is primarily used for the treatment of prostate cancer (especially at stage D2 when the cancer has spread to other parts of the body) and hirsuitism.
Cancer
Generic
Cyclophosphamide

Cyclophosphamide 50mg

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Usage

This medicine is mainly used for treating various types of cancer. Cyclophosphamide is a chemotherapy drug that works by stopping or slowing cell growth. It is a medication that interferes with the growth as well as spread of cancer cells in the body. Cyclophosphamide tablet is also very effective in treating certain cases of nephrotic syndrome which is kidney disease found in children.  

It works by decreasing the immune system’s response to different diseases. Cyclophosphamide generic drug is available in the brand name of Cytoxan.  

Cyclophosphamide dose

The dosage of this medicine based upon the medical condition, weight, response to treatment as well as other treatments you may be receiving such as radiation and chemotherapy drugs. Strictly follow the directions written on your prescription label. Do not use this medicine in larger or smaller amounts or for longer time than recommended. It is given sometimes as a pill or liquid. This medicine is also given as an injection sometimes into a vein through an IV.  

In order to prevent harmful effects on your bladder, drink plenty of liquids during the intake of this medicine. Measure the liquid medicine with the help of dosing syringe which is provided with medicine itself or with a special dose-measuring spoon or medicine cup. If you need surgery make sure that you inform your doctor before the surgery that you are using this medicine. Cyclophosphamide turns to be very harmful if it gets on your skin. If this happens, wash your skin immediately with soap and water.  

Keep checking your blood often as this medicine can lower blood cells that help your body in fighting infections. Store this medicine at room temperature right away from moisture as well as heat.  

Make sure that you take the missed dose as soon as you remember. But if it’s time for your next dose then miss the skipped dose and take only the next regularly scheduled dose as prescribed by your doctor. Do not take the two doses at the same time. Contact your doctor immediately if you have missed the dose of Cyclophosphamide injection.  

Cyclophosphamide side effects 

During the intake of this medicine, there are chances that you might experience vomiting, nausea, stomach ache, loss of appetite, diarrhea as well as darkening of the skin and nails.  

Call your doctor immediately, if you suffer from: 

  • Pain or burning when you urinate, blood in your stools or urine
  • Feeling light-headed, pale skin, trouble in concentrating and rapid heart rate
  • Feeling short of breath on exertion, dry cough or hack, sudden pain in chest or discomfort as well as wheezing
  • Body ache, flu symptoms, fever, chills and sores in your mouth as well as throat
  • Jaundice, vomiting, weakness as well as extreme thirst with headache
  • Severe skin reaction like sore throat, fever, burning in your eyes, swelling in your face or tongue and skin pain which is followed by red or purple skin rashes that spread and often causes peeling and blistering

Some of the common side effects of using this medicine are:

  • Temporary hair loss, wound that does not heal, changes in skin color
  • Diarrhea, stomach pain or upset
  • Temporary hair loss
  • Missed menstrual periods
  • Changes in nails or changes in skin color
  • Therefore, this is not the complete list of side effects, if anything happens apart from this consult your doctor immediately.

This medicine also has some serious side effects on the heart when used in high doses or combination with radiation treatment or with certain chemotherapy drugs. Intake of this medicine can lower your body’s ability to fight against the infection. So if you develop any signs of infection, call your doctor immediately. 

Cyclophosphamide Precautions 

Before the intake of this medicine, inform your doctor if you are allergic to it or any other chemotherapy drugs like chlorambucil as well as if any other allergies. Since this medicine contain certain inactive ingredients so there are chances that it can cause allergic reactions or other problems. This medicine can pass into body fluids like in feces, urine and vomit.  

Caregivers should always wear rubber gloves at the time of cleaning up patient’s body fluids, handling contaminated trash, laundry or changing diapers. One needs to avoid being near the people who are sick or have infections. If you develop any signs of infection, immediately inform your doctor.  

Do not receive any live vaccine while using this medicine and also for at least three months after your treatment ends. One should also avoid coming in contact with the person who has recently received a live vaccine because there are chances that the virus could be passed on to you. Live vaccines include mumps, measles, typhoid, yellow fever, varicella, zoster, rotavirus, rubella as well as nasal flu vaccine.      

In case you have certain medical conditions then do not use this medicine without consulting your doctor. If you have decreased bone marrow function then consult your doctor before the intake of this medicine. Before you start using this medicine, make sure that you tell your doctor about your complete medical history especially if you suffer from kidney disease, liver disease as well as surgery to remove your adrenal glands.  

Without the consent of your doctor, do not have immunizations or vaccinations. This drug can be absorbed through skin and lungs as well as harm the unborn baby, so women who are pregnant or who may become pregnant should not use this medicine. This medicine should not be used by breastfeeding mothers as it passes into breast milk.  

Cyclophosphamide interactions 

There are total 252 drugs that are known to interact with Cyclophosphamide. 

39 major drug interactions

183 moderate drug interactions

30 minor drug interactions 

Cyclophosphamide MOA (Mechanism of Action) 

This medicine comes in a class of medications known as alkylating agents. When this medicine is used for treating cancer, it works by stopping or slowing the growth of cancer cells in your body. It also works by suppressing the body’s immune system when this medicine is used for treating nephrotic syndrome.  

Cyclophosphamide Warnings 

This medicine should strictly not be used if you are suffering from severe bone marrow suppression. During the intake of this medicine, it is important to monitor complete blood counts so that dose can be adjusted. 


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